# NAD+ Research References: Cited Literature > Full citation list for NAD+ research on MD NAD — PubMed links, DOIs, and complete bibliographic information for every study cited across the site. ## About these references Every quantitative claim on this site maps to a numbered citation in this list. All citations are from PubMed-indexed journals, PubMed Central, or peer-reviewed conference proceedings. DOI links and PubMed URLs are provided for each entry. ## References [1] Camacho-Pereira J, Tarragó MG, Chini CCS, et al. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. *Cell Metabolism.* 2016;23(6):1127-1139. https://pubmed.ncbi.nlm.nih.gov/27304511/ DOI: 10.1016/j.cmet.2016.05.006 [2] Covarrubias AJ, Kale A, Perrone R, et al. Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. *Nature Metabolism.* 2020;2(11):1265-1283. https://pubmed.ncbi.nlm.nih.gov/33199924/ DOI: 10.1038/s42255-020-00305-3 [3] Irie J, Inagaki E, Fujita M, et al. Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. *Endocrine Journal.* 2020;67(2):153-160. https://pubmed.ncbi.nlm.nih.gov/31685720/ DOI: 10.1507/endocrj.EJ19-0313 [4] Okabe K, Yaku K, Uchida Y, et al. Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. *Frontiers in Nutrition.* 2022. https://pubmed.ncbi.nlm.nih.gov/35309539/ DOI: 10.3389/fnut.2022.868640 [5] Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. *Science.* 2021;372(6547):1224-1229. https://pubmed.ncbi.nlm.nih.gov/33888596/ DOI: 10.1126/science.abe9985 [6] Yi L, Maier AB, Tao R, et al. The efficacy and safety of beta-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. *GeroScience.* 2022;45(1):29-43. https://pubmed.ncbi.nlm.nih.gov/36482258/ DOI: 10.1007/s11357-022-00705-1 [7] Igarashi M, et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. *NPJ Aging.* 2022;8(1):5. https://pubmed.ncbi.nlm.nih.gov/35927255/ DOI: 10.1038/s41514-022-00084-z [8] Conze D, Brenner C, Kruger CL. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. *Scientific Reports.* 2019;9:9772. https://pubmed.ncbi.nlm.nih.gov/31278280/ DOI: 10.1038/s41598-019-46120-z [9] Grant R, Berg J, Mestayer R, et al. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+. *Frontiers in Aging Neuroscience.* 2019;11:257. https://pubmed.ncbi.nlm.nih.gov/31572171/ DOI: 10.3389/fnagi.2019.00257 [10] Reyna K, Heinzen G, Patel N, et al. Intravenous infusion of nicotinamide adenine dinucleotide (NAD+) versus nicotinamide riboside (NR): a retrospective tolerability pilot study in a real-world setting. *Frontiers in Aging.* 2026. https://pubmed.ncbi.nlm.nih.gov/41704678/ DOI: 10.3389/fragi.2026.1652582 [11] Blum K, Han D, Baron D, et al. Nicotinamide Adenine Dinucleotide (NAD+) and Enkephalinase Inhibition Infusions Significantly Attenuate Psychiatric Burden Sequalae in Substance Use Disorder in Fifty Cases. *Current Psychiatry Research Review.* 2022. https://pubmed.ncbi.nlm.nih.gov/36118157/ DOI: 10.2174/2666082218666220527114427 [12] Braidy N, Villalva MD, van Eeden S. Sobriety and Satiety: Is NAD+ the Answer? *Antioxidants (Basel).* 2020;9(5):425. https://pubmed.ncbi.nlm.nih.gov/32423100/ DOI: 10.3390/antiox9050425 [13] Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. *Rejuvenation Research.* 2017;20(3):244-247. https://pubmed.ncbi.nlm.nih.gov/28537485/ DOI: 10.1089/rej.2017.1980 [14] Nakahata Y, Sahar S, Astarita G, Kaluzova M, Sassone-Corsi P. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. *Science.* 2009;324(5927):654-657. https://pubmed.ncbi.nlm.nih.gov/19286518/ DOI: 10.1126/science.1170803 [15] Grozio A, Mills KF, Yoshino J, et al. Slc12a8 is a nicotinamide mononucleotide transporter. *Nature Metabolism.* 2019;1(1):47-57. https://pubmed.ncbi.nlm.nih.gov/31131364/ DOI: 10.1038/s42255-018-0009-4 [16] Christen S, Redeuil K, Goulet L, et al. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans. *Nature Metabolism.* 2026. https://pubmed.ncbi.nlm.nih.gov/41540253/ DOI: 10.1038/s42255-025-01421-8 [17] Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners. *Journal of the International Society of Sports Nutrition.* 2021;18(1):54. https://pubmed.ncbi.nlm.nih.gov/34238308/ DOI: 10.1186/s12970-021-00442-4 [18] Berven H, Kverneng S, Sheard E, et al. NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease. *Nature Communications.* 2023;14:7793. https://pubmed.ncbi.nlm.nih.gov/38016950/ DOI: 10.1038/s41467-023-43514-6 [19] Vinten KT, Tretowicz MM, Coskun E, et al. NAD+ precursor supplementation in human ageing: clinical evidence and challenges. *Nature Metabolism.* 2025;7(10):1974-1990. https://pubmed.ncbi.nlm.nih.gov/41083806/ DOI: 10.1038/s42255-025-01387-7 [20] Orr ME, Kotkowski E, Ramirez P, et al. A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment. *GeroScience.* 2024. https://pubmed.ncbi.nlm.nih.gov/37994989/ DOI: 10.1007/s11357-023-00999-9 [21] Bohr VA. Promising Results With NAD Supplementation in Rare Diseases With Premature Aging and DNA Damage. *Aging Cell.* 2025. https://pubmed.ncbi.nlm.nih.gov/41436848/ DOI: 10.1111/acel.70319 [22] Massudi H, Grant R, Braidy N, et al. Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue. *PLoS One.* 2012;7(7):e42357. https://pubmed.ncbi.nlm.nih.gov/22848760/ DOI: 10.1371/journal.pone.0042357 [23] de Guia RM, Agerholm M, Nielsen TS, et al. Aerobic and resistance exercise training reverses age-dependent decline in NAD+ salvage capacity in human skeletal muscle. *Physiological Reports.* 2019;7(12):e14139. https://pubmed.ncbi.nlm.nih.gov/31207144/ DOI: 10.14814/phy2.14139 --- Chrome-console readings of the peer-reviewed NAD+ record — clinical trials indexed, infusion rates logged, no prescriptions filled.